Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity  

作　　者：Soichi Sano Hiroki Ueno Keiko Yamagami Yosuke Yakushiji Yoshihiro Isaka Isao Kawasaki Masashi Takemura Takeshi Inoue Masayuki Hosoi 

机构地区：[1]Department of Internal Medicine, Osaka City General Hospital, Osaka 534-0021, Japan [2]Department of Metabolism and Endocrinology, Osaka City General Hospital, Osaka 534-0021, Japan [3]Department of Gastrointestinal Surgery, Osaka City General Hospital, Osaka 534-0021, Japan [4]Department of Pathology, Osaka City General Hospital, Osaka 534-0021, Japan

出　　处：《World Journal of Gastroenterology》2010年第26期3339-3342,共4页世界胃肠病学杂志（英文版）

摘　　要：We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based onthese observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly.We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency ...

关 键 词：Terbinafi ne Drug hypersensitivity Human herpesvirus 6 CYTOMEGALOVIRUS Intestinal perforation ILEUM 

分 类 号：R593[医药卫生—内科学]