饮酒与乙肝病毒感染对肝脏损伤的协同作用及机制的研究进展  

Progress in synergetic effects and mechanisms of alcohol consumption and hepatitis B infection on liver injury

作　　者：黄娟娟[1,2] 刘世坤[1,2] 

机构地区：[1]中南大学湘雅三医院药剂科 [2]中南大学药学院,湖南长沙410013

出　　处：《中国药理学与毒理学杂志》2010年第3期228-231,共4页Chinese Journal of Pharmacology and Toxicology

摘　　要：饮酒和乙肝病毒感染是造成肝脏损伤的两大病因。流行病学调查显示,在慢性肝病患者中,饮酒及HBV感染两种损伤因素多并存。饮酒与HBV感染促进肝脏损伤的发生和进展,促进肝细胞癌的发生。饮酒可促进体内HBV的病毒复制和基因突变,而HBV感染亦可增加肝细胞对乙醇损伤的易感性。这些研究为临床肝病患者的保健和治疗提供了依据。本文从临床表现、临床研究和实验机制研究等方面综述了饮酒与HBV感染对肝脏损伤的协同作用及其机制。Alcohol consumption and hepatitis B virus (HBV) infection,both recognized as major causes of chronic liver disease,frequently coexist in patients with chronic liver disease.Alcohol consumption and HBV infection promote the development and progression of liver disease and increase the risk of hepatocellular carcinoma.Alcohol consumption stimulates HBV gene replication and mutation in HBV carriers.On the other hand,HBV infection aggradates alcohol-induced cytotoxicity in habitual drinkers.This serves as the t...

关 键 词：饮酒 肝炎病毒 乙型 肝 

分 类 号：R512.62[医药卫生—内科学]