Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups  

作　　者：Bi, Yun Mei Gong, Xiao Ying Wang, Wen Zhao Yu, Li Hu, Min Qi Shao, Li Dong 

机构地区：[1]Yunnan Normal Univ, Coll Chem & Engn, Kunming 650092, Peoples R China [2]Chongqing Coll Sci & Technol, Coll Chem & Chem Engn, Chongqing 40042, Peoples R China

出　　处：《Chinese Chemical Letters》2010年第2期237-241,共5页中国化学快报（英文版）

基　　金：the National Natural Foundation of China(No. 20364002);the Natural Science Foundation of Yunnan Province(No.2005B0027 M),China

摘　　要：Two novel biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups were synthesized via the macromolecular substitution reactions of poly(dichlorophosphazene) with the sodium salt of lactic acid ester and sodium methoxyethoxyethoxide.Their structures were confirmed by ^(31)p NMR,~1H NMR,^(13)C NMR,IR,DSC,and elemental analysis.The lower critical solution temperature(LCST) behavior in water and in vitro degradation property of the polymers was investigated.The...Two novel biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups were synthesized via the macromolecular substitution reactions of poly(dichlorophosphazene) with the sodium salt of lactic acid ester and sodium methoxyethoxyethoxide.Their structures were confirmed by ^(31)p NMR,~1H NMR,^(13)C NMR,IR,DSC,and elemental analysis.The lower critical solution temperature(LCST) behavior in water and in vitro degradation property of the polymers was investigated.The...

关 键 词：POLYPHOSPHAZENE Lactic acid ester Methoxyethoxyethoxy BIODEGRADATION Thermosensitive polymer 

分 类 号：O631.3[理学—高分子化学]