Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles  

作　　者：Li, Ying Jun Liu, Li Jun Jin, Kun Xu, Yong Ting Sun, Su Qin 

机构地区：[1]Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Peoples R China [2]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

出　　处：《Chinese Chemical Letters》2010年第3期293-296,共4页中国化学快报（英文版）

基　　金：supported by the Education Office of Liaoning Province(No.2008345)

摘　　要：A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5- [2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various(un)substituted aromatic acids in the presence of phosphorous oxychloride.These compounds were investigated for their inhibitory activity to E.coli methionine aminopeptidase(EcMetAP1).Some of the tested compounds showed significant inhibitory activity.

关 键 词：Triazolo-thiadiazoles SYNTHESIS Bioactivity 

分 类 号：O621.25[理学—有机化学]