The heavy atom effect on photocleavage of DNA by mono-hydroxyl halogenated corroles  

作　　者：Chi Kwong Chang 

机构地区：[1]Department of Chemistry,The Hong Kong University of Science and Technology

出　　处：《Chinese Chemical Letters》2010年第3期373-375,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.20771039,20625205, 20871122,20971046);National Key Foundation Research Development Project(973) Item of China(No. 2007CB815306)

摘　　要：DNA photocleavage properties of halogenated mono-hydroxyl corrole 1-5 were investigated.It was found that these corroles were able to photocleavage supercoiled pBR 322 DNA（SC） into nicked-circular DNA（NC）.The activity of these corroles follows an order of 4>3>2≈1>5.The photosensitized singlet oxygen（Φ;） quantum yield by these corroles also follows that same order,showing the photocleavage activity is related to the heavy atom effect of halogen atoms on corroles.DNA photocleavage properties of halogenated mono-hydroxyl corrole 1-5 were investigated.It was found that these corroles were able to photocleavage supercoiled pBR 322 DNA(SC) into nicked-circular DNA(NC).The activity of these corroles follows an order of 4>3>2≈1>5.The photosensitized singlet oxygen(Φ_△) quantum yield by these corroles also follows that same order,showing the photocleavage activity is related to the heavy atom effect of halogen atoms on corroles.

关 键 词：CORROLE DNA PHOTOCLEAVAGE Heavy atom effect 

分 类 号：O643.12[理学—物理化学]