异丙嗪对普鲁卡因致惊厥半数有效量的影响  

Effect of promethazine on median effective dose of convulsion induced by procaine

作　　者：郭艳[1] 程雪淋[1] 朱颖君[1] 刘亚君[1] 戴体俊[2] 

机构地区：[1]徐州医学院麻醉学院,徐州221002 [2]徐州医学院麻醉药理学教研室,徐州221002

出　　处：《世界临床药物》2009年第11期670-671,共2页World Clinical Drug

基　　金：国家自然科学基金资助项目(30872432;30471657;39970715);江苏省自然科学基金资助项目(BK 200143)

摘　　要：目的观察异丙嗪对普鲁卡因致惊厥半数有效量(ED_(50))的影响。方法30只小鼠随机分为实验组(腹腔注射异丙嗪)和对照组(腹腔注射生理盐水),采用序贯实验法测定两组小鼠普鲁卡因腹腔注射的致惊厥半数有效量(ED_(50))。结果实验组普鲁卡因致惊厥ED_(50)为177.6 mg/kg,相应的对照组为137.7 mg/kg,两组差异具有统计学显著性(P<0.05)。结论异丙嗪对普鲁卡因致惊厥具有一定保护作用。Objective To observe the effect of promethazine on median effective dose(ED_(50)) of convulsion induced by procaine.Methods Thirty mice were divided into experimental group and control group.Sequential method was used for the measurement of ED_(50).Results The ED_(50) of experimental group and control group were 177.6 mg/kg and 137.7 mg/kg respectively,and the difference between two groups was significant(P<0.05).Conclusion Promethazine is helpful to prevent convulsion induced by procaine.

关 键 词：异丙嗪 普鲁卡因 惊厥 序贯 

分 类 号：R96[医药卫生—药理学]