糖尿病周围神经病变的高同型半胱氨酸血症及甲钴胺干预后变化  

The plasma homocysteine level in diabetic peripheral neuropathy and its change after mecobalamine treatment

作　　者：张国栋[1] 龚慧[1] 盛宏光[2] 黄佳佳[1] 叶菲[1] 田秀丽[1] 徐茜[1] 张杉杉[1] 汤正义[1] 宁光[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病临床中心上海市内分泌代谢病研究所,上海200025 [2]上海市徐汇区中心医院内分泌代谢病科,上海200031

出　　处：《世界临床药物》2009年第11期672-675,共4页World Clinical Drug

摘　　要：目的观察糖尿病周围神经病变(DPN)患者和非糖尿病周围神经病变(NDPN)患者的血浆同型半胱氨酸(Hcy)水平及甲钴胺的疗效。方法115例2型糖尿病患者经临床和实验室检查后分为DPN或NDPN组,DPN组随机分为甲钴胺组和腺苷钴胺组治疗4周,分别测定治疗前后血浆Hcy水平,评估神经症状。结果DPN组患者血浆Hcy水平与NDPN组患者类似,均较正常值升高;短期治疗,甲钴胺和腺苷钴胺对神经病变疗效基本一致;甲钴胺治疗后,血浆Hcy显著下降(P<0.05),而腺苷钴胺于治疗前后无显著差异(P>0.05)。结论DPN患者血浆Hcy水平升高,甲钴胺治疗可降低患者血浆Hcy水平,改善神经症状。Objective To investigate plasma homocysteine level between diabetic peripheral neuropathy(DPN) and non-diabetic peripheral neuropathy(NDPN) in type 2 diabetic patients,and to evaluate the effect with mecobalamine. Methods Totally 115 type 2 diabetic patients were divided into DPN and NDPN groups.Patients with DPN were treated with mecobalamine or cobamamide for 4 weeks.Plasma homocysteine level was tested and the neurologic symptoms severity were evaluated before and after treatment.Results Patients with ty...

关 键 词：糖尿病神经病变 同型半胱氨酸 甲钴胺 腺苷钴胺 

分 类 号：R587.2[医药卫生—内分泌]