卡维地洛对原发性高血压患者的肾脏保护作用  

Effects of carvedilol on the renal function in patients with essential hypertension

作　　者：吴奇志[1] 张敏[1] 李敏[1] 翁朝航[1] 范可军[1] 陈志松[1] 陈孝良[1] 

机构地区：[1]厦门大学附属中山医院湖里分院内科,厦门361006

出　　处：《世界临床药物》2009年第12期735-738,共4页World Clinical Drug

摘　　要：目的探讨卡维地洛对原发性高血压(EH)患者肾功能的影响。方法56例EH患者经2周冲洗期后,接受卡维地洛一日2次,每次10 mg口服,疗程16周。治疗4周后若舒张压仍然≥90mmHg则剂量加倍,观察治疗前后血压和肾功能各项指标的变化。结果治疗后患者收缩压由(156.2±11.8)mmHg降至(134.5±10.9)mmHg,舒张压由(101.5±3.7)mmHg降至(85.3±5.6)mmHg,治疗前后相比,差异有统计学意义的显著性(P<0.01);24 h尿白蛋白由(107.2±50.1)mg降至(69.5±31.2)mg(P<0.01);24 h尿总蛋白由(0.28±0 071)g/L降至(0.19±0.049)g/L(P<0.01);血β_2微球蛋白(β_2-MG)由(2.43±0.45)mg/L降至(1.82±0.41)mg/L(P<0.01);尿β_2-MG由(0.124±0.038)mg/L降至(0.109±0.016)mg/L(P<0.01)。治疗前后肾小球滤过率,血尿素氮、肌酐和内生肌酐清除率,血糖,血脂,血电解质等的差异均无统计学意义(P>0.05)。结论卡维地洛能显著降低EH患者的收缩压和舒张压,且能减少其24 h尿白蛋白的排泄,降低血、尿β_2-MG,对患者的肾功能具有保护作用。Objective To evaluate the effects of carvedilol on the renal function in patients with essential hypertension. Methods After two weeks of washout,56 patients were administered carvedilol 10 mg twice daily for 16 weeks. Dose double was required if diastolic blood pressure≥90mmHg after 4 weeks of treatment.Blood pressure,serum creatinine(Cr),blood urea nitrogen(BUN),endogenous creatinine clearance rate(Ccr),24 h total urine protein(UTP) and albumin(Alb),serum and urineβ_2-microglobulin(β_2-MG) were measured b...

关 键 词：卡维地洛 高血压 原发性 肾功能 保护 

分 类 号：R544.1[医药卫生—心血管疾病]