抗真菌药物的联合应用  

Combination of antifungal medications

作　　者：沈银忠[1] 张永信[2] 

机构地区：[1]复旦大学附属公共卫生临床中心,上海201508 [2]复旦大学附属华山医院,上海200040

出　　处：《世界临床药物》2009年第12期721-725,共5页World Clinical Drug

基　　金：上海市卫生局青年科研项目(编号:2008Y030)

摘　　要：近年来侵袭性真菌感染的发病率呈上升趋势,但临床抗真菌疗效仍有待提高。为了提高抗真菌疗效,临床医生常联合应用多种抗真菌药物。不同的联合治疗方案在不同的侵袭性真菌感染治疗中的价值不尽相同。随着新型高效低毒抗真菌药物的出现和应用,临床上出现了多种可能的联合用药方案,但联合用药的确切价值尚需通过临床研究加以验证,联合用药不宜作为侵袭性真菌感染最初的常规治疗方案,且应遵循个体化原则。In recent years,the incidence of invasive fungal infections(IFI) as being increased.Antifungal combinations are increasingly used in clinical practice to improve outcomes for refractory mycoses because of the suboptimal efficacy.Different combinations have different values in terms of the types of IFI.The availability of new antifungal medications with novel mechanisms of action has stimulated renewed interest in the combination of antifungal therapies,however,the efficacy and safety of combined antifungal ...

关 键 词：侵袭性真菌感染 隐球菌脑膜炎 侵袭性曲霉病 侵袭性念珠菌病 联合治疗 

分 类 号：R519[医药卫生—内科学]