腺苷、左旋精氨酸对动脉化静脉的保护的实验研究  

The experimental study of adenosine l-adenosine l-arginine to arteriallization vein prote ction tian maoliang

作　　者：田茂良[1] 李矿[1] 武志[2] 陈祥青[1] 吴茂军[1] 高松[1] 

机构地区：[1]泰山医学院附属医院,山东泰安271000 [2]禹城市人民医院,山东禹城251200

出　　处：《泰山医学院学报》2009年第12期902-904,共3页Journal of Taishan Medical College

摘　　要：目的研究腺苷、左旋精氨酸对兔颈外静脉移植至股动脉后的保护作用,并探讨可能的机制。方法40只新西兰大白兔随机分为A、B、C、D四组,每组10只。各组获取颈外静脉后,A组颈静脉作为正常对照组,B、C、D组作为桥血管端-端吻合于股动脉,每日分别经耳缘静脉给予B组-腺苷、C组-左旋精氨酸、D组-生理盐水各1周,于术后4周取血管桥标本,用40%甲醛固定,石蜡包埋,制成5μm切片,常规脱蜡至水,行HE染色和弹力纤维染色,光镜下观察、测定移植静脉内膜中膜厚度变化。结果移植后血管狭窄程度观察:移植4周后,各组静脉均有内膜及中膜较正常颈静脉明显增厚表现,腺苷及左旋精氨酸组内膜及中膜增厚较对照组轻。内膜中膜厚度分别为:A组(51.15±2.64)、B组(74.02±2.15)、C组(80.98±2.25)、D组(98.54士4.34),可见单纯手术组>左旋精氨酸干预组>腺苷干预组>正常对照组,各组之间P=0.000,均小于0.05,有统计学意义。结论1.兔颈外静脉移植至股动脉后内膜及中膜增厚。2.腺苷及左旋精氨酸能抑制动脉化静脉内膜及中膜增厚,有减轻桥静脉狭窄的作用。Objective:To study the protective effects of adenosine and L-arginine on the external jugular vein after being transplanted into femoral artery and explore its possible mechanism.Methods: Forty New Zealand rabbits were randomly divided into four groups:group A、group B、group C and group D,10 rabbits in each group.Made the external jugular veins of group A as the control group,while those of group B、group C and group D were transplanted into femoral arteries by end to end.then adenosine、 L-arginine and saline...

关 键 词：静脉 动脉化 腺苷 左旋精氨酸 

分 类 号：R654.2[医药卫生—外科学]