兴安藜芦中甾体生物碱成分的研究  

Steroidal alkaloids of from Veratrum dahuricum

作　　者：赵朗[1] 欧志强[1] 王刊[1] 付宏征[1] 

机构地区：[1]北京大学天然药物与仿生药物国家重点实验室,北京100191

出　　处：《中国中药杂志》2009年第23期3039-3042,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30772639)

摘　　要：目的:对兴安藜芦Veratrum dahuricum中甾体生物碱成分进行研究。方法:利用硅胶,凝胶和反相硅胶等色谱技术进行分离纯化,通过NMR,MS等波谱学方法鉴定化合物结构。结果:从兴安藜芦中鉴定出5个化合物,分别为(20R,22S,25S)-veratra-5,13-dien-3β-ol(1),当归酰棋盘花碱(angeloylzygadenine,2),15-O-(2-methylbutanoyl)-3-O-veratroylprotoverine(3),20-isoveratramine(4),藜芦胺(veratramine,5)。结论:化合物1为新化合物,2~4为首次从该植物中分离得到。Objective:To study the steroidal alkaloids in Veratrum dahuricum.Method: The compounds were isolated and purified by various column chromatographic methods.Their structures were identified by spectroscopic analysis.Result: Five compounds were isolated and identified as(20R,22S,25S)-veratra-5,13-dien-3β-ol(1),angeloylzygadenine(2),15-O-(2-methylbutanoyl)-3-O-ve-atroylprotoverine(3),20-isoveratramine(4),veratramine(5).Conclusion: Compound 1 was a new compound,compounds 2-4 were obtained from the plant for the...

关 键 词：兴安藜芦 甾体生物碱 

分 类 号：R284[医药卫生—中药学]