面心设计——效应面法优化巴布剂基质的研究  

Optimization of cataplasm matrix with face-centered design-response surface method

作　　者：刘淑芝[1] 李军红[1] 金日显[1] 杜茂波[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2009年第24期3211-3213,共3页China Journal of Chinese Materia Medica

基　　金：国家"十一五"科技支撑计划项目(2006BAI09B08-13);科技部"重大新药创制"科技重大专项中药关键技术(2009ZX09502-010)

摘　　要：目的:优化巴布剂基质处方。方法:采用面心设计,考察自变量卡波姆、聚丙烯酸钠、交联剂等因素对因变量初黏力的影响,拟合二次多项式方程,结合效应面法,优选较佳处方,并进行预测分析。结果:二次多项式拟合方程复相关系数R2=0.970,Ad j-R2=0.952,方差分析F四归=53.953,P=0.000 1,模型高度显著;效应面法分析确定了巴布剂基质较佳处方,验证实验结果满意。结论:面心设计-效应面法应用于巴布剂基质的优化,方法简便,预测性良好。Objective:To optimize the matrix formulation of cataplasm.Method:Face-centered design was used in the experimental design,and response surface was produced in quadratic polynomial after data fitting in order to explore the impacts of Sodium Polyacrylate,Carbomer and the cross-linking agent on stickiness of cataplasm,optimize the prescription of the cataplasm matrix and perform the evaluation analysis.Result:The multiple correlation coefficient(R2) and adjusted R2 in the fitting method using quadratic polyno...

关 键 词：巴布剂 面心设计-效应面优化 初黏力 卡波姆 聚丙烯酸钠 

分 类 号：R944[医药卫生—药剂学]