西洋参干预胰岛素抵抗大鼠活性部位的化学成分研究  

Studies on Chemical Constituents of Active Site that American Ginseng Impact Rat Insulin Resistance

作　　者：李冀[1] 马育轩[1] 葛鹏玲[1] 石鑫[1] 吴全娥[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2009年第6期68-70,130,共4页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金项目(30672632);黑龙江省杰出青年科学基金项目(JC04-01)

摘　　要：目的:研究西洋参干预胰岛素抵抗大鼠的化学成分。方法:以醇提取,用大孔树脂吸附,乙醇洗脱得总皂苷,再用硅胶柱色谱、及HPLC等现代分离技术与方法分离和纯化,通过理化常数及光谱数据确定其结构。结果:共分得3个化合物,经鉴定后分别证明为:3-O-β-D-吡喃葡萄糖基-(1-2)-β-D-吡喃葡萄糖基-20-O-β-D-呋喃阿拉伯糖基-(1-6)-β-D-吡喃葡萄糖基-达玛-24-稀-3β,12β,20S-三醇(Ⅰ)、3-O-β-D-吡喃葡萄糖基-(1-2)-β-D-吡喃葡萄糖基-20-O-β-D吡喃葡萄糖基-达玛-24-稀-3β,12β,20S-三醇(Ⅱ)、3-O-β-D-吡喃葡萄糖基-(1-2)-β-D-吡喃葡萄糖基-达玛-24-烯-3β,12β,20S-三醇(Ⅲ)。Objective:To study the chemical constituents of active site that American ginseng treats rat insulin resistance.Methods:They were extracted by ethanol and adsorbed by macro2reticular resins,then eluted with ethanol and isolated by silica gel column chromatography and HPLC preparation chromatography.Their structures were determined by physical and chemical properties,as well as spectrographical identification.Results:Three compounds were isolated from the active site th American ginseng treats rat insulin re...

关 键 词：西洋参 活性部位 胰岛素抵抗 化学成分 

分 类 号：R284.1[医药卫生—中药学]