Preparation of a novel biodegradable β-cyclodextrin-containing polymer  

作　　者：朱久进 

机构地区：[1]School of Chemical and Biological Engineering,Chongqing University of Technology [2]Research Center of Bioinspired Materials Science and Engineering,College of Bioengineering,Chongqing University

出　　处：《Journal of Chongqing University》2009年第4期217-221,共5页重庆大学学报（英文版）

基　　金：Funded by the Natural Science Foundation of China(No.50603032);Education Commission of Chongqing(No.KJ090617);the Science and Technology Plan Project of Jiulongpo District,Chongqing,China(No.2008Q95)

摘　　要：A novel cyclodextrin-containing polymer was prepared by graftingβ-cyclodextrin onto the backbone of poly(D,L-lactic acid)(PLA).First,mono(6-(2-aminoethyl)amino-6-deoxy)-β-cyclodextrin(β-CD-6-en)was prepared by sulfonylation and amination ofβ-cyclodextrin and modified poly(D,L-lactic acid)(MPLA)was prepared by free radical polymerization of maleic anhydride and PLA.Then,grafting ofβ-cyclodextrin derivative to MPLA backbone was carried out by N-acylation reaction of MPLA andβ-CD-6-en in dimethyl formamide.The...A novel cyclodextrin-containing polymer was prepared by graftingβ-cyclodextrin onto the backbone of poly(D,L-lactic acid)(PLA).First,mono(6-(2-aminoethyl)amino-6-deoxy)-β-cyclodextrin(β-CD-6-en)was prepared by sulfonylation and amination ofβ-cyclodextrin and modified poly(D,L-lactic acid)(MPLA)was prepared by free radical polymerization of maleic anhydride and PLA.Then,grafting ofβ-cyclodextrin derivative to MPLA backbone was carried out by N-acylation reaction of MPLA andβ-CD-6-en in dimethyl formamide.The synthetic polymer(PLA-β-CD)was characterized by FTIR(Fourier transform infrared)spectroscopy and proton nuclear magnetic resonance(1H NMR)spectroscopy.The results demonstrated that,in the context of remaining the chain structure of PLA,the content ofβ-CD-6-en is 1.6%by the developed synthetic method.

关 键 词：poly（D L-lactic acid） Β-CYCLODEXTRIN β-cyclodextrin polymer chemical modification 

分 类 号：O631.3[理学—高分子化学]