Concentration polarization of atherogenic lipids in the arterial system  

作　　者：邓小燕 王贵学 

机构地区：[1]Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, Chongqing University, Chongqing 400044, China,State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian 116023, China [2]Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, Chongqing University, Chongqing 400044, China

出　　处：《Science China(Life Sciences)》2003年第2期153-164,共12页中国科学（生命科学英文版）

基　　金：This work was supported by the Whitaker Foundation of USA; and the Quebec Biomaterials Insti-tute; Canada; and the National Natural Science Foundation of China (Grant No. 10172027).

摘　　要：The transport of atherogenic lipids (LDL) in a straight segment of an artery with a semi-permeable wall was simulated numerically. The numerical analysis predicted that a mass transport phenomenon called 慶oncentration polarization?of LDL might occur in the arterial system. Under normal physiological flow conditions, the luminal surface LDL concentration was 5%—14% greater than the bulk concentration in a straight segment of an artery. The luminal surface LDL concentration at the arterial wall was flow-dependent, varying linearly with the filtration rate across the arterial wall and inversely with wall shear rate. At low wall shear rate, the luminal surface LDL concentration was very sensitive to changes in flow conditions, decreasing sharply as wall shear rate increased. In order to verify the numerical analysis, the luminal surface concentration of bo-vine serum albumin (as a tracer macromolecule) in the canine carotid artery was measured in vitro by directly taking liquid samples from the luminal surface of the artery. The experimental result was in very good agreement with the numerical analysis. The authors believe that the mass transport phenomenon of 慶oncentration polarization?may indeed exist in the human circulation and play an important role in the localization of atherosclerosis.The transport of atherogenic lipids (LDL) in a straight segment of an artery with a semi-permeable wall was simulated numerically. The numerical analysis predicted that a mass transport phenomenon called 慶oncentration polarization?of LDL might occur in the arterial system. Under normal physiological flow conditions, the luminal surface LDL concentration was 5%—14% greater than the bulk concentration in a straight segment of an artery. The luminal surface LDL concentration at the arterial wall was flow-dependent, varying linearly with the filtration rate across the arterial wall and inversely with wall shear rate. At low wall shear rate, the luminal surface LDL concentration was very sensitive to changes in flow conditions, decreasing sharply as wall shear rate increased. In order to verify the numerical analysis, the luminal surface concentration of bo-vine serum albumin (as a tracer macromolecule) in the canine carotid artery was measured in vitro by directly taking liquid samples from the luminal surface of the artery. The experimental result was in very good agreement with the numerical analysis. The authors believe that the mass transport phenomenon of 慶oncentration polarization?may indeed exist in the human circulation and play an important role in the localization of atherosclerosis.

关 键 词：mass transport  CONCENTRATION polarization  WALL SHEAR rate  atherosclerosis. 

分 类 号：R318.0[医药卫生—生物医学工程]