Time resolve study on isopropyl-ether porphyrindiol  

作　　者：张连文 姚思德 林维真 陈志龙 

机构地区：[1]Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, Shanghai 201800, China [2]2. Department of Chemistry, Liaocheng University, Liaocheng 252059, China [3]Department of Radiation Medical, the Second Military Medical University of Shanghai, Shanghai 200433, China

出　　处：《Science China Chemistry》2003年第1期51-56,共6页中国科学（化学英文版）

基　　金：The author Zhang Lianwen thanks Prof. Zheng Zhide and Zhang Wenlong for their technical support in the experiment. This work was supported by the National Natural Science Foundation of China (Grant No. 39830090) and the Ninth-Five Year Key Project of Chi

摘　　要：A novel fat-soluble porphyrin derivative—isopropyl-ether porphyrindiol (IPEP) has been investigated using the nanosecond laser photolysis and pulse radiolysis. In acetonitrile, IPEP-excited triplet state shows two relative absorption areas peaking at 320 and 430 nm, molar extinction coefficients by energy transfer method (in benzene solution) are proved to be ε (315) = 1.07}105, ε (450)=3.3}104 L3 · mo-1 · cm-1 and the excited triplet state quantum yield by comparative method is 0.18. Laser photolysis of IPEP in dGMP-containing solution shows that the triplet state cannot excite/oxidize dGMP via the energy/electron transfer process.A novel fat-soluble porphyrin derivative—— isopropyl-ether porphyrindiol (IPEP) has been investigated using the nanosecond laser photolysis and pulse radiolysis. In acetonitrile, IPEP-excited triplet state shows two relative absorption areas peaking at 320 and 430 nm, molar extinction coefficients by energy transfer method (in benzene solution) are proved to be e (315) = 1.07×105, e (450) = 3.3×104 L3·mol-1·cm-1 and the excited triplet state quantum yield by com-parative method is 0.18. Laser photolysis of IPEP in dGMP-containing solution shows that the trip-let state cannot excite/oxidize dGMP via the energy/electron transfer process.

关 键 词：laser photolysis  PULSE radiolysis  EXCITED TRIPLET state  photodynamic therapy  isopropyl-ether porphyrindiol. 

分 类 号：O626[理学—有机化学]