血清抗子宫内膜抗体与体外受精-胚胎移植结果的关系  

The relationship between serum endometrial antibody and the results of in vitro fertilization-embryo transfer

作　　者：沙爱国[1] 任建枝[1] 郑仁瑞[1] 李萍[1] 邱慧玲[1] 

机构地区：[1]解放军第174医院生殖医学中心,福建厦门361003

出　　处：《东南国防医药》2003年第2期90-92,共3页Military Medical Journal of Southeast China

摘　　要：目的 探讨血清抗子宫内膜抗体与体外受精-胚胎移植结果相关性。方法 分析IVF-ET101个起始周期、86个移植周期的临床资料,按女性血清抗子宫内膜抗体存在与否分为两组(阳性组、阴性组),比较两组间年龄、周期取消率、平均Gn用量、平均卵泡数、回收卵子率、受精率、卵裂率、优质胚胎率、平均移植胚胎数及临床妊娠率的差别。结果 阳性组与阴性组;分别平均年龄为(32.81±4.01)岁与(31.44±3.99)岁;周期取消率14.29％与15.38％;平均Gn用量(30.87±5.40)支与(29.73±6.18)支;平均卵泡数(11.02±5.48)个与(12.36±5.91)个;取卵率75.44％与78.30％;受精率71.58与74.05％;卵裂率96.97％与95.57％;优质胚胎率41.88％与40.63％及平均移植胚胎数(3.69±1.29)个与(4.03±1.40)个。两组间比较均无显著性差异(P>0.05)。阳性组与阴性组:移植周期临床妊娠率分别为21.43％与45.45％,两组间比较有非常显著性差异(P<0.01)。结论 血清抗子宫内膜抗体可能干扰了IVF-ET中的胚胎着床或胚胎发育,体内自身抗体的存在是IVF-ET的失败原因之一。Objective To study the association of serum endometrial antibody and the outcome of in vitro fertilization-embryo transfer (IVF-ET). Methods 101 initiated cycles and 86 embryo transfer cycles were divided into two groups according to the presence of endometrial antibodies in female serum. The results of two groups were compared with the age, rate of cancel cycles, average number of follicles, rate of oocytes recovered, fertilization rate, cleavage rate, rate of high quality embryo and pregnancy rate. Results There is no significant difference (P>0. 05) in the age, rate of cancel cycle, average number of follicle, rate of oocyte recovered, fertilization rate, cleavage rate and rate of high quality embryo. There was signifficant differences (P<0. 01) in the pregnancy rate of the two groups. Conclusions The serum endometrial antibody can disturb embryo to implant IVF-ET. The existence of autoantibody in the patient with endometriosis may play a role in the failure of IVF-ET.

关 键 词：体外受精-胚胎移植 不孕症 血清抗子宫内膜抗体 

分 类 号：R711.6[医药卫生—妇产科学]