随机对照研究苦参素对乙肝肝纤维化的疗效  

Randomized controlled trial of oxymatrine therapy for hepatic fibrosis in patients with chronic hepatitis B

作　　者：高作文[1] 李新慧[1] 周燕[1] 齐承义[1] 

机构地区：[1]解放军第81医院当涂分院感染科,安徽当涂243100

出　　处：《东南国防医药》2003年第2期94-96,共3页Military Medical Journal of Southeast China

摘　　要：目的 研究苦参素(氧化苦参碱)治疗慢性乙型肝炎肝纤维化的临床疗效。方法 采用随机分组将80例患者分为治疗组和对照组,对照组以口服甘草甜素为主,治疗组在此基础上加苦参素600mg肌注,前3个月每日一次,后3个月隔日一次;观察治疗前、治疗3个月及6个月时血清HA、PCⅢ、LN的变化。结果 治疗6个月后治疗组血清HA、PCⅢ、LN均低于对照组,治疗组中上述3项指标逐渐降低,但治疗6个月时仍高于体检健康者。同时服用甘草甜素与苦参素的患者血清HA、PCⅢ、LN均有显著性降低,HA从(298.83±133.33)μg/L、降至(221.32±95.69)μg/L(P<0.01),PCⅢ从(205.35±84.57)μg/L降至(183.13±61.65)μg/L(P<0.01),LN由(167.48±58.05)μg/L降至(136.92±42.86)μg/L(P<0.01)。仅服用甘草甜素的患者除LN没有显著变化外(P>0.05),HA、PCⅢ都有明显上升(P<0.05)。结论 苦参素具有抗纤维化作用,疗程越长,效果越明显。Objective To research the effect of oxytna trine on hepatic fibrosis in patients with chronic hepatitis B. Methods Eighty patients were divided into trial groups randomly, the control group (n=40) received glycyrrhizin 450mg daily, the trial group (n = 40) received 600 mg oxymatrine and 450mg glycyrrhizin. One time a day for first 3-month, one time two days for next 3-month. Serum levels of HA.pc Ⅲ , LN were measured. Results Patients receivd oxymatrine and glycyrrhizin, serum levels of HA.PCⅢ. ,LN decreased, HA level from (298. 83±133. 33) μg/L to (221. 32 ± 95. 69)μg/L(P<0. 01), PC ± level from (205. 35 ± 84. 57)μg/L to (183. 13 ± 61. 65)μg/L(P<0. 01), LN level from (167. 48±58. 05)/μg/L to (136. 92 ± 42. 86)μg/I.(P<0. 01 ). Patients only receivd glycyrrhizin. serum levels of HA,PC Ⅲ increased significantly(P<0. 05) except no significant changing in LN level(P>0. 05). Conclusions Oxymatrine is beneficial for treating hepatic fibrosis in patients with chronic hepatitis B.

关 键 词：氧化苦参碱 肝纤维化 病毒性乙型肝炎 慢性 

分 类 号：R512.6+2[医药卫生—内科学]