RELATIONSHIP BETWEEN THE EXPRESSIONS OF LMP1 AND ECADHERIN/β-CATENIN IN NASOPHARYNGEAL CARCINOMA  

作　　者：LIN Su-xia ZONG Yong-sheng CHU Bing ZHONG Bi-ling LI Zhi LIANG Ying-jie LIN Han-liang 林素暇;宗永生;储兵;钟碧玲;李智;梁英杰;林汉良(Department of Pathology,Sun Yat-sen Medical College,Sun Yat-sen University,Guangzhou 510089;Department of Pathology,Zhongshan Municipal People’s Hospital,Zhongshan City 528400)

机构地区：[1]Department of Pathology,Sun Yat-sen Medical College,Sun Yat-sen University,Guangzhou 510089 [2]Department of Pathology,Zhongshan Municipal People’s Hospital,Zhongshan City 528400

出　　处：《Chinese Journal of Cancer Research》2002年第3期202-205,共4页中国癌症研究(英文版)

基　　金：This work was supported by the National Natural Science Foundation of China(No.39730200-II).

摘　　要：Objective:To compare the expression of Epstein-Barr virus encoded LMP1 and E-cadherin/β-catenin in primary and metastatic nasopharyngeal carcinoma(NPC)for the purpose of understanding their relationship.Methods:Twenty-two pairs of biopsies taken from the nasopharynx and cervical lymph node(s)of the same patient with nasopharyngeal carcinoma were collected.The expression of LMP1,E-cadherin andβ-catenin was observed on immunostained slides using LSAB method.Results:The expression rate of LMP1 in the 22 metastatic tumors(86.36%,19/22)was significantly higher than that in the 22 primary growths(68.18%,15/22),P<0.05.The mean expression percentages of E-cadherin andβ-catenin in metastatic tumors(50.11%±22.53%and 66.36±21.05%,respectively)were significantly lower than those in primary growths(71.52±24.34%and 79.40%±15.05%,respectively),P<0.05.There was a positive correlation between the expressions of E-cadherin andβ-catenin either in primary growths or metastatic tumors.Conclusion:The LMP1 is more likely to be expressed in metastatic neoplastic cells of NPC than in primary carcinoma cells,and on the contrary the expression of E-cadherin/β-catenin in metastatic cells was decreased.Accordingly,the LMP1 might have the ability to downregulate the expression of E-cadherin/β-catenin,resulting in enhancement of the invasive capacity of metastatic NPC cells.

关 键 词：Nasopharyngeal tumor LMP1 E-CADHERIN Β-CATENIN INVASIVENESS 

分 类 号：Q939-63[生物学—微生物学]