Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection  

作　　者：DENG Guang-hui WEI Shou-lian MO Jin-yuan 

机构地区：[1]Department of Chemistry,Guangxi University for Nationalities,Nanning 530006,P.R.China [2]Department of Chemistry,Zhongshan University,Guangzhou 510275,P.R.China

出　　处：《Chemical Research in Chinese Universities》2002年第1期16-19,共4页高等学校化学研究(英文版)

基　　金：Supported by the Natural Science Foundation of Guangxi Province(No.9912 0 0 1)

摘　　要：In the nonaqueous N,N -dimethylformamide medium, the chiral drugs ibuprofen and terbutaline were successfully separated with sulfonyl- β -cyclodextrin(s- β -CD) as the chiral selector by capillary electrophoresis with conductance detection. The comparison of the effects of three CDS( β -CD, diethylic- β -CD, sulfonyl- β -CD) on the chiral separation was made and the resolution mechanism was proposed.In the nonaqueous N,N -dimethylformamide medium, the chiral drugs ibuprofen and terbutaline were successfully separated with sulfonyl- β -cyclodextrin(s- β -CD) as the chiral selector by capillary electrophoresis with conductance detection. The comparison of the effects of three CDS( β -CD, diethylic- β -CD, sulfonyl- β -CD) on the chiral separation was made and the resolution mechanism was proposed.

关 键 词：Nonaqueous medium Capillary electrophoresis with conductance detection Sulfonyl β -CD Resolution N N -Dimethylformamide 

分 类 号：O658.9[理学—分析化学]