Hydrolysis Reactions and Resolution of (±)-2-Acetamido-3-hydroxy-1-(4-nitrophenyl)-1-propanone  

作　　者：YANG Hui QIU Guo-fu FENG Xichun HE Jian-she HU Xian-ming 

机构地区：[1]College of Pharmacy,Wuhan University,Wuhan 430072,P.R.China

出　　处：《Chemical Research in Chinese Universities》2002年第4期409-411,共3页高等学校化学研究(英文版)

基　　金：Supported by the Science and Technology Fund of Wuhan City( No.9960 0 10 16G)

摘　　要：The hydrolysis reaction of (±)-2-acetamido-3-hydroxy-1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]1], an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone, an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]3] was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)- was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)-3.The hydrolysis reaction of (±)-2-acetamido-3-hydroxy-1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]1], an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone, an intermediate of chloramphenicol, was studied and three different products were obtained respectively under different reaction conditions. The resolution of hydrolysis product (±)-2-amino-3-hydroxy- 1-(4-nitrophenyl)-1-propanone[(±)-[STHZ]3] was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)- was carried out. A process of crystallization-induced asymmetric transformation was observed and up to 76% of the optically pure enantiomer was obtained in the resolution of (±)-3.

关 键 词：HYDROLYSIS RESOLUTION EPIMERIZATION 

分 类 号：O625[理学—有机化学]