含1,4-二氢吡啶环的新烟碱类化合物的合成及杀虫活性  

Synthesis and insecticidal activity of neonicotinoids containing 1,4-dihydropyridine ring

作　　者：吴宁波[1] 陈卫东[1] 须志平[1] 杨小宝[2] 徐晓勇[1] 

机构地区：[1]上海市化学生物学重点实验室华东理工大学药学院,上海200237 [2]上海东岳生物化工有限公司,上海200237

出　　处：《农药学学报》2010年第2期119-126,共8页Chinese Journal of Pesticide Science

基　　金：上海市科委和教委资助项目(09391911800;073919107;B507)

摘　　要：通过NTN32692、芳香醛和氰基乙酸乙酯参与的多组份反应合成了15个全新的含1,4-二氢吡啶环的新烟碱类化合物,其结构均经过核磁共振氢谱、高分辨质谱、红外光谱确证。室内生物测定结果表明,目标化合物对孑孓Culex pipiens pallens、粘虫Pseudaletia separateWalker和蚜虫Aphis craccivora具有较高的杀虫活性,部分化合物在质量浓度为500mg/L下对粘虫和蚜虫的致死率可达到100%。Fifteen new neonicotinoid compounds containing 1,4-dihydropyridine ring have been synthesized via multicomponent reactions of NTN32692,aromatic aldehydes and ethyl cyanoacetate.All the synthesized compounds were confirmed by 1H NMR,HRMS and IR spectroscopy.The insecticidal activity tests were determined on Culex pipiens pallens,Pseudaletia separate Walker and aphid Aphis craccivora.The results showed that some of target compounds exhibited significant insecticidal activity on P.separate and aphid Aphis crac...

关 键 词：新烟碱类 NTN32692 1 4-二氢吡啶环 多组份反应 杀虫活性 

分 类 号：S482.3[农业科学—农药学]