5-(羟基亚甲基)-2,4-咪唑啉二酮酯的合成及除草活性  

Synthesis and herbicidal activity of 5-(4-hydroxymethylene) hydantoin esters

作　　者：韩金涛[1] 陈守聪[1] 刘吉平[1] 徐志红[1] 邱立红[1] 王明安[1] 

机构地区：[1]中国农业大学应用化学系,北京100193

出　　处：《农药学学报》2010年第3期274-278,共5页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金(20772150);国家高技术研究发展计划("863"计划)项目(2006AA10A209);"十一五"国家科技支撑计划资助项目(2006BAE01A01);中国农业大学研究生科研创新专项资金资助

摘　　要：在实验室原有的AdSS酶抑制剂研究工作基础上,以丝氨酸为原料设计合成了9个未见文献报道的2,4-咪唑啉二酮酯类化合物,其结构经核磁共振氢谱、红外光谱、元素分析或质谱等验证。初步生物活性测试结果表明,化合物3g在质量浓度200μg/mL下对拟南芥Arabidopsis thaliana的发芽抑制率达到70%,表现出一定的除草活性。Nine novel esters containing 2,4-imidazolinedione (hydantoin) were synthesized using serine as the starting material based on the research of AdSS inhibitors carried out in the laboratory.Their structures were confirmed by IR,1H NMR spectral data and elemental analysis.The preliminary bioassay results showed that compound 3g had 70% germination inhibitory rate against Arabidopsis thaliana at the concentration of 200 μg/mL,which indicated that this compound has herbicidal activity.

关 键 词：AdSS抑制剂 2 4-咪唑啉二酮酯 合成 除草活性 

分 类 号：TQ457[化学工程—农药化工]