成都市区成人血尿素水平和相关影响因素分析及参考区间建立  

Source of Variations of Serum Urea Levels and Consideration of Reference Interval in Urban Chengdu

作　　者：吕瑞雪[1] 李一松[1] 黄志刚[1] 王佑娟[2] 彭志英[1] 

机构地区：[1]四川大学华西医院实验医学科临床生化室,成都610041 [2]四川大学华西医院健康检查中心,成都610041

出　　处：《四川大学学报（医学版）》2010年第4期684-687,共4页Journal of Sichuan University(Medical Sciences)

基　　金：中华医学基金会(CMB;00737)"实验室认可项目"资助

摘　　要：目的探讨影响成都市区成人血尿素水平的相关因素,并建立健康成人血尿素的医学参考区间。方法收集成都市区17787例体检者血尿素检测值,分析其分布特点,并同时分析其与肝功、肾功、血葡萄糖、血脂检测各定量项目间的相互影响关系,建立参考区间。结果除性别、年龄外,肌酐(Crea)、尿酸(Uric)、血糖(Glu)、高密度脂蛋白胆固醇(HDL-C)水平升高可致成人尿素水平一定程度升高,球蛋白(Glb)水平降低可能导致成人尿素水平升高;其中Crea、Glu、HDL-C对尿素水平的影响在正常健康成人仍存在。健康成人男性各年龄段尿素水平高于女性;男性和女性在30岁、50岁、60岁、70岁前后尿素水平随年龄都出现了有意义的增长。结论成都市区健康成人血尿素水平在男性和女性的不同年龄段存在差异,并可受血Crea、Glu、HDL-C一定程度影响,可考虑根据性别和年龄段分别建立血尿素医学参考区间。Objective To determine the serum Urea levels in healthy adults living in urban Chengdu and to identify factors that influence the serum urea levels for the purpose of establishing reference interval.Methods Serum urea levels were determined in 17 787 healthy adults in urban Chengdu who underwent physical examinations.The characteristics of distribution of serum urea levels in the population and its relationships with liver function,renal function,serum glucose,and serum lipid were analyzed.Results Increased Crea,Uric,Glu,and HDL-C levels and decreased Glb level were associated with increased serum urea levels,which was independent of the impact of sex and age.The association between serum urea and Crea,Glu, and HDL-C existed in normal healthy adults.Men had higher urea levels than women.Regardless of gender,serum urea increased with age(with a cut off point at 30,50,60 and 70 years).Conclusion Serum urea levels in healthy adults living in urban Chengdu vary in different gender and age groups.Serum urea levels are associated with serum Crea,Glu,the HDL-C levels.It is necessary to establish gender and age-specific reference intervals for serum urea.

关 键 词：尿素 参考值 参考区间 

分 类 号：R446.11[医药卫生—诊断学]