Th17细胞及其分化调控机制研究进展  

Progress on Th17 Cell and Regulative Mechanism for Its Differentiation

作　　者：滕素玲[1] 郑世民[1] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030

出　　处：《动物医学进展》2010年第9期89-92,共4页Progress In Veterinary Medicine

基　　金：黑龙江省自然科学基金项目(C200841);黑龙江省教育厅项目(11511031)

摘　　要：辅助性T细胞17(T help cell 17,Th17)是2005年发现的能够分泌白细胞介素17的CD4+T细胞,其与Th1、Th2、Tregs共同构成CD4+T细胞的4个亚群。该细胞的分化受多种细胞因子和信号分子精细而复杂地调控。转化生长因子-β(TGF-β)I、L-6I、L-23和RORγt在Th17细胞的分化形成过程中起着积极的促进作用,而Socs3和Ets-1则抑制它的分化。论文对Th17细胞及其分化调控机制的研究进展做一简要综述。T help 17(Th17)cell,which was first found in 2005 and is characterized by the release of interleukin(IL)-17,constitutes four subtypes of CD4+ T cells together with Th1,Th2 and regulatory T(Tregs) cells.Th17 cell differentiation is regulated by a variety of cytokines and signaling molecules.TGF-β,IL-6,IL-23 and RORγt play an important role in promoting Th17 cell’s differentiation,while Socs3 and Ets-1 inbitit the process.In this paper,research advances in Th17 cell and regulative mechanism for its differentiation were summarized.

关 键 词：TH17细胞 白细胞介素-17 分化调控 

分 类 号：S852.4[农业科学—基础兽医学]