越南城市地区年轻人患结核病的增加未影响人群结核感染危险率的降低  

Decrease in risk of tuberculosis infection despite increase in tuberculosis among young adults inurban Vietnam

作　　者：T.N.Buu H.T.Quy N.C.Qui N.T.N.Lan D.N.Sy F.G.J.Cobelens 范永德 王雪静 

机构地区：[1]Pham Ngoc Thach Tuberculosis and Lung Disease Hospital,Ho Chi Minh City,Ho Chi Minh Province [2]National Tuberculosis Program and Central Tuberculosis and Lung Disease Hospital,Ha Noi City,Vietnam [3]KNCV Tuberculosis Foundation,The Hague [4]Centre for Poverty-related Communicable Diseases,Centre for Infection and Immunity Amsterdam,Academic Medical Centre,Amsterdam,The Netherlands

出　　处：《国际结核病与肺部疾病杂志》2010年第3期289-295,共8页The International Journal of Tuberculosis and Lung Disease

摘　　要：目的:评价越南年轻成年人的结核病登记率增加是否造成结核病在大众人群中传播的增加。方法:使用1996—2005年间县/区级结核病防治机构常规报告的数据计算出新涂阳结核登记率的趋势。对6～9岁儿童进行结核菌素调查,使用其结果计算结核年感染危险率的趋势。结果:自1996年至2006年间,15～24岁年龄组结核病登记率的年增长率为4.3%,且城市地区的年增长率(6.7%)比农村地区(1.7%)更高。城市地区的结核年感染危险率从1992年的2.4%下降到1998年的1.2%和2005年的0.9%;摘要农村地区的结核年感染危险率从1991年的0.7%上升到1997年的1.2%,之后下降到2006年的0.9%。结论:在胡志明省,年轻成年人结核病登记率升高,但同时儿童结核年感染危险率下降。这说明年轻成年人的结核病登记率变化趋势反映了在这一年龄段从结核菌感染发展成为结核病患者的比例升高了,以及/或在这一年龄段的结核病传播增加了,但不能说结核病在全人群中的传播增加了。OBJECTIVE: To assess whether the increase in tuberculosis (TB) notification rates among young adults in Vietnam reflects increased transmission in the population at large. METHOD: Trends of case notification rates of new smear-positive TB were calculated from routinely reported data of district TB units over the period 1996C2005. Results from repeated tuberculin surveys among children aged 6C9 years were obtained to calculate the trend in annual risk of TB infection (ARTI). FINDINGS: From 1996 to 2006, notification rates in the age group 15C24 years increased by 4.3% per year, and more so in highly urbanised (6.7%) than in rural districts (1.7%). The ARTI in urban districts declined from 2.4% in 1992 to 1.2% in 1998 and 0.9% in 2005. In rural districts, the ARTI increased from 0.7% in 1991 to 1.2% in 1997, and then declined to 0.9% in 2006. CONCLUSION: The increase in TB notification rates among young adults in Ho Chi Minh Province is accompanied by a decrease in ARTI in children. This suggests that the trend in TB notification among young adults reflects increased rates of progression from infection to disease and/or increased transmission within this age group, rather than increased transmission in the population at large.

关 键 词：结核感染率 病例登记 越南城市地区 

分 类 号：R181.3[医药卫生—流行病学]