N-羧甲基壳聚糖的制备表征及性能研究  

Preparation,Characterization and Properties of N-carboxymethyl Chitosan

作　　者：孙立苹[1] 杜予民[2] 

机构地区：[1]浙江林学院环境科技学院,浙江杭州311300 [2]武汉大学资环学院,湖北武汉430072

出　　处：《环境科学与技术》2010年第11期62-65,共4页Environmental Science & Technology

基　　金：浙江省教育厅项目(Y200907046)

摘　　要：通过乙醛酸与壳聚糖形成西佛碱,用硼氢化钠还原制备N位取代的羧甲基壳聚糖,采用FT-IR、X-ray、NMR分析手段对分子结构进行表征。吸湿保湿性能研究发现取代度较低的N-羧甲基壳聚糖吸湿性能较好,保湿性能随着羧甲基取代度的增加而增强。通过羟基磷灰石、骨胶原与N-羧甲基壳聚糖制备了新型的复合生物材料,与没有添加N-羧甲基壳聚糖的复合材料相比较,发现具有良好的机械性能和溶涨性能。N-carboxymethyl chitosan was prepared by adding glyoxylic acid and sodium hydroxide,with its molecular structure characterized by FT-IR,XRD and NMR.Its moisture-absorption and retention abilities were also studied.New composite biomaterial was made from hydroxyapatite and collagen conjugated with N-carboxymethyl chitosan.The structure evaluation of composite showed more dense arrangement due to formation of collagen-N-carboxymethyl chitosan conjugate,and particles of inorganic component were closely anchore...

关 键 词：N-羧甲基壳聚糖 结构表征 吸湿保湿 复合材料 骨修复 

分 类 号：R318.08[医药卫生—生物医学工程]