羊膜上皮细胞的干细胞样特性  

Stem cell-like characteristics of amniotic epithelial cells

作　　者：汤宇[1] 谢佳芯[1] 许家军[1] 

机构地区：[1]第二军医大学人体解剖学教研室

出　　处：《解剖科学进展》2010年第5期478-482,共5页Progress of Anatomical Sciences

基　　金：国家重点基础研究发展计划资助项目(No.2005CB724302)

摘　　要：干细胞移植技术面临的最大问题就是干细胞的选择和来源。羊膜上皮细胞(AEC)具有向一些三胚层(外胚层、中胚层和内胚层)细胞分化的潜能及类似干细胞的特性,免疫原性低且具有抗炎症作用,移植后无致瘤性和排斥反应。羊膜是产后废弃物,来源丰富,无伦理问题。因此,AEC在干细胞移植及再生医学上有广阔的应用前景,正逐步成为干细胞移植的理想来源。The most difficult problem in stem cells transplantation is the selection and source of stem cells. Recent researches demonstrated that amniotic epithelial cells(AEC) had potential to differentiate to some three germ layers (ectoderm,mesoderm and endoderm) cells,and had characteristics resembling stem cells including anti-inflammatory,low immunogenic characteristics,non-tumorigenicity and no rejection reaction after transplantation.Amnion is abundant in source and no ethical problem,discarded after parturition.Thus,AECs,which have broad application prospect for stem cell transplantation and regenerative medicine,have started to become an ideal material of stem cell transplantation.

关 键 词：胚胎干细胞 神经细胞分化 上皮细胞 干细胞移植 免疫原性 羊膜 体外培养 可表达 细胞表达 肝细胞 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]