测定血清TRAb、HA在Graves眼病中的临床意义  

Serum detection of TRAb and HA in patients with Graves ophthalmopathy and their clinical significance

作　　者：韦华[1] 李凤玲[1] 方文珠[2] 吴明清[3] 

机构地区：[1]广西右江民族医学院附属医院内分泌科,533000 [2]广西右江民族医学院附属医院核医学科,533000 [3]广西右江民族医学院附属医院眼科,533000

出　　处：《中国现代医药杂志》2010年第7期19-21,共3页Modern Medicine Journal of China

摘　　要：目的探讨促甲状腺素受体抗体(TRAb),透明质酸(HA)在Graves眼病(GO)发病机制中的作用。方法采用放射免疫分析法、放射受体分析法测定Graves眼病(GO)患者98例(根据甲状腺功能状态分为GO1组46例、GO2组52例)、Graves病无眼病(NGO)患者50例和正常对照组30例血清FT3、FT4、s-TSH、TRAb和血清HA水平。结果①GO1和NGO组的TRAb浓度明显高于正常对照组(P<0.01),GO1和GO2组HA浓度明显高于正常对照组(P<0.01);②活动性的GO患者TRAb浓度与非活动性比较无差异(P>0.05),而HA明显高于非活动性且有统计学意义(P<0.01);③Graves病患者血FT3与TRAb浓度呈正相关,相关系数为0.21(P<0.01)。HA浓度与血甲状腺激素和TSH均无明显相关性。结论 TRAb参与GD的发生,HA在GO的发病中起相关作用。Objective To investigate the value of serum thyrotropin receptor antibody (TRAb), hyaluronic acid (HA) in patients with Graves ophthalmopathy. Methods Using radioimmunoassay,serum values of FT3,FT4,s-TSH,TRAb and HA were detected in 98 patients with Graves’ophthalmopathy (GO,this group subdivided into GO1,GO2), 50 patients with no Graves’ ophthalmopathy (NGO) and 30 normal controls. Results ①Serum TRAb in GO1 group and NGO group were significantly higher than in normal control group(P0.05), but serum HA in patients with active GO was significantly higher than in patients no with active (P<0.01), ③Serum FT3 and TRAb in patients with Graves disease to be positive correlation (P<0.01), but serum HA was no related to FT3,FT4,TSH in patients with Graves disease. Conclusion Serum TRAb plays a vital role in Graves disease. Serum HA be involved in the development of Graves’ ophthalmopathy.

关 键 词：GRAVES眼病 GRAVES病 促甲状腺素受体抗体 透明质酸 

分 类 号：R581.1[医药卫生—内分泌]