A New Approach to 2,3-Dihydro-1H-1,5-Benzodiazepines from the Reaction of o-Nitrophenylazide with α,β-Unsaturated Ketones Promoted by Samarium Diiodide  

作　　者：Xiao Yuan CHEN Wei Hui ZHONG Yong Min ZHANG 

机构地区：[1]Department of Chemistry,Zhejiang University at Xixi Campus,Hangzhou 310028 [2]Laboratory of Organometallic Chemistry,Chinese Academy of Sciences,Shanghai 200032 [3]Department of Chemistry,Hunan Jishou University,Jishou416000

出　　处：《Chinese Chemical Letters》2001年第1期5-6,共2页中国化学快报(英文版)

基　　金：We thank the National Natural Science Foundation of China (Project No.29872010) ; NSF of Zhejiang province for financial support.

摘　　要：o-Nitrophenylazide was reduced by SmI2 in anhydrous THF at room temperature to produce active intermediate 2 (samarium amide), "living" double-anion in situ which reacted smoothly with α，β-unsaturated ketones to afford 2,3-dihydro-1H-1,5-benzodiazepines in good yields under mild and neutral conditions.o-Nitrophenylazide was reduced by SmI2 in anhydrous THF at room temperature to produce active intermediate 2 (samarium amide), "living" double-anion in situ which reacted smoothly with α,β-unsaturated ketones to afford 2,3-dihydro-1H-1,5-benzodiazepines in good yields under mild and neutral conditions.

关 键 词：Samarium diiodide reduction nitro group azide 2 3-dihydro-1H-1 5-benzodiazepine. 

分 类 号：O625[理学—有机化学]