Establishment of transgenic mouse harboring hepatitis B virus (adr subtype) genomes  

作　　者：Yi Ping Hu1 Wei Jiang Hu1 Wen Chao Zheng2 Jian Xiu Li1 De Shun Dai1 Xin Min Wang1 Shu Zhong Zhang1 Hong Yu Yu3 Wei Sun4 Guang Rong Hao4 1Department of Cell Biology, Second Military Medical University, Shanghai 200433, China2University of Wisconsin, Madison, WI 53705, USA3Department of Pathology, Second Military Medical University, Shanghai 200433, China4Center of laboratory Animals, Second Military Medical University, Shanghai 200433, China 

出　　处：《World Journal of Gastroenterology》2001年第1期111-114,共4页世界胃肠病学杂志（英文版）

基　　金：This work was supported by Projects of Tackling Key Problems in Science;Technology from the State Science;Technology Ministry (TJ99-LA01); Shanghai Science;Technology Commission (994919033 )

摘　　要：INTRODUCTIONHepatitis B virus (HBV) belongs to the group ofhepatovirus, a major pathogen of human acute andchronic hepatitis B[1 4], which has a very closeassociation with human hepatocellular carcinoma(HCC)[5-8], For example, a statistical data from ahospital in Shanghai showed that 80% of HCCpatients were positive for HBsAg ( personalcommunication).

关 键 词：Genome  Viral Animals Antibodies  Viral DNA  Viral Disease Models  Animal Gene Expression Regulation  Viral Hepatitis B Hepatitis B Core Antigens Hepatitis B Surface Antigens Hepatitis B virus Kidney Liver MICE Mice  Transgenic MICROINJECTIONS Microscopy  Electron Polymerase Chain Reaction Research Support  Non-U.S. Gov't Virus Integration 

分 类 号：R512.62[医药卫生—内科学]