Synthesis of Conformationally LockedIsonucleosides: 2'-Deoxy-2'-nucleobase-5'-deoxy-1', 4' : 3' , 6'-dianhydro-D-mannitol  

作　　者：TIAN Xiao-bing, ZHANG Ling, MIN Ji-mei and ZHANG Li-he (School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, P. R. China) LU Yang, JIANG Reng-wang and ZHENG Qi-tai (Institute of Materia Medica, Peking Union Medical College &. Ch 

出　　处：《Chemical Research in Chinese Universities》2001年第2期178-185,共9页高等学校化学研究（英文版）

基　　金：the National Natural Science Foundation of China.

摘　　要：Novel bicyclic isonucleosides, 2′-deoxy-2′ -nucleobase-5′-deoxy-1′ , 4′ : 3′ , 6′ -dianhydro- D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu- lation indicated that the sugar conformations of compounds 10a-10c were restricted to N-con- formation.Novel bicyclic isonucleosides, 2′-deoxy-2′ -nucleobase-5′-deoxy-1′ , 4′ : 3′ , 6′ -dianhydro- D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu- lation indicated that the sugar conformations of compounds 10a-10c were restricted to N-con- formation.

关 键 词：Bicyclic isonucleoside Locked conformation SYNTHESIS 

分 类 号：O629[理学—有机化学]