Graft Polymerization of Acryloyloxystarch with Poly (D, L-lactide) Macromonomer——A Potential Drug Delivery Carrier for Oral Administration  

作　　者：WANG Li-qun TU Ke-hua WANG Yan-bing LI Xiang-rong 

机构地区：[1]Department of Polymer Science and Engineering [2]College of Medicine of Zhejiang University,Hangzhuo 310027,P.R.China [3]Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai 200433,P.R.China

出　　处：《Chemical Research in Chinese Universities》2001年第3期334-337,共4页高等学校化学研究(英文版)

基　　金：Supported by the Natural Science Foundation of China, the Natural Science Foundation of Zhejiang Province and the Visiting Scholarship of the Key Laboratory of Molecular Engineering of Polymers at Fudan University, the Ministry of Education of China.

摘　　要：Starch is the second largest natural biopolymer. Its unique biodegradable and biocompatible properties make it be increasingly applied to the field of biomedicine. As one kind of polysaccharide, starch is easily degraded into small organic molecules by amylase in the alimentary canal. The fact that the activity of amylase is restrained in the high acid environment in stomach provides an opportunity to prepare an intestinal-specific delivery carrier withStarch is the second largest natural biopolymer. Its unique biodegradable and biocompatible properties make it be increasingly applied to the field of biomedicine[1~4]. As one kind of polysaccharide, starch is easily degraded into small organic molecules by amylase in the alimentary canal. The fact that the activity of amylase is restrained in the high acid environment in stomach provides an opportunity to prepare an intestinal-specific delivery carrier with starch. In order to protect the drugs that are sensitive to the enzyms in alimentary canal, a hydrophobic layer should be constructed between the outer bioadhensive shell and the drug.

关 键 词：Acryloyloxystarch PLA macromonomer Graft copolymerization 

分 类 号：TQ464[化学工程—制药化工]