Synthesis of 5-Substituted-3-[(2’R,4’R)-4’-Hydroxy-2’-hydroxymethyltetrahydrofuran-4’-yl]-1,2,4-oxadiazoles and Their Epimers  

作　　者：WU Wei-dong MA Ling-tai ZHANG Li-he 

机构地区：[1]National Laboratory of Natural and Biomimetic Drugs,School ofPharmaceutical Sciences,Peking University,Beijing 100083,P.R.China

出　　处：《Chemical Research in Chinese Universities》2001年第4期407-414,共8页高等学校化学研究(英文版)

基　　金：National Natural Science Foundation of China.

摘　　要：The syntheses of 5-substituted-3-[( 2’ R, 4’ R)-4 ’ -hydroxy-2 ’ -hydroxymethyltetra-hydrofuran-4’ -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.The syntheses of 5-substituted-3-[( 2' R, 4' R)-4 ' -hydroxy-2 ' -hydroxymethyltetra-hydrofuran-4' -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.

关 键 词：Nucleoside analogue 1 2 4-Oxadiazole Transacylation 

分 类 号：O626[理学—有机化学]