Study on the Supramolecular Inclusion Complex of β-Cyclodextrin/Lappaconitine  

作　　者：Liao Kaijun 

出　　处：《Chemical Research in Chinese Universities》2001年第z1期166-167,共2页高等学校化学研究（英文版）

摘　　要：Lappaconitine (Lap) is a diterpenoid akaliamide, naturally occurring in roots and rhizomes of Aconitum and delphinium. Lap reveals bradycardic, hypotensive, antinocieptive activity. However, its application is restrained owing to its poor water solubility, toxicity and side effects on humans. In a number of pharmaceutical studies,CDs have been reported to interact with many drug molecules to form inclusion complexes. These inclusion complexes have been extensively used to improve water solubility of poorly soluble drugs, to reduce their toxicity, and to increase the dissolution rate [1]. In the present work, the β-CD/Lap complex was prepared by kneading method. The products have been characterized by the solubility measurement as well as UV, FTIR, NMR spectroscopy and X-ray powder diffractometry. 　　……

分 类 号：O6[理学—化学]