系膜增生性肾小球肾炎患儿肾组织TGF-β1的表达与临床病理意义  

Expression of transforming growth factor-β1 (TGF-β1) in mesangial proliferative glomerulonephritis (MsPGN) and its effects

作　　者：邵晓珊 蒋新辉 李宇红 靳蓉 仝铁 

机构地区：[1]贵阳市儿童医院肾脏免疫科,550003 [2]贵阳市儿童医院病理科,550003

出　　处：《贵州医药》2011年第4期297-300,共4页Guizhou Medical Journal

摘　　要：目的探讨转化生长因子-β1(transforming growth factor-β1,TGF-β1)蛋白在系膜增生性肾小球肾炎(MsPGN)肾组织中的表达及其临床意义。方法应用即用型免疫组化方法(Elivision二步法)检测MsPGN25例、微小病变(MCNS)10例、局灶性节段肾小球硬化(FSGS)8例、对照组5例,观察TGF-β1蛋白在系膜增生性肾小球肾炎患儿肾组织中的表达情况。结果 (1)在不同病理类型患儿肾小球上皮细胞及肾小管间质细胞均有不同程度的TGF-β1蛋白的阳性表达,TGF-β1的表达以FSGS为最强,其次为MsPGN、MCNS。与正常肾组织比较差异有统计学意义(P<0.001);(2)MsPGN组TGF-β1蛋白表达随着系膜增生程度明显增加(P<0.01);(3)MsPGN组随肾小管间质损伤和炎症细胞浸润程度及纤维化程度加重,TGF-β1蛋白表达明显增加(P<0.01);(4)MsPGN肾组织TGF-β1表达水平与蛋白尿严重程度相关。结论 MsPGN肾组织内TGF-β1的表达增强,并与肾脏病理损伤程度密切相关。Objective To explore the expressions of transforming growth factor-β1(TGF-β1) in the kidneys of children with mesangial proliferative glomerulonephritis(MsPGN),and to explore the possible clinical mechanisms of mesangial proliferative glomerulonephritis.Methods 43 patients were enrolled in the study.Among them,10 patients were diagnosed with MCNS,25 with MsPGN,8 with FSGS.5 children were enrolled as normal control.The expressions of TGF-β1 were evaluated with immunohistochemical techniques.Results(1) The ex...

关 键 词：系膜增生性肾小球肾炎 儿童 转化生长因子TGF-Β1 肾小管间质损伤 

分 类 号：R726.9[医药卫生—儿科]