噻吩甲酰基吡唑啉酮缩氨基酸稀土配合物的合成、表征及生物活性  

Synthesis, Characterization and Bioactivity of Rare Earth Complexes of Thenoylpyrazolone-amino-acid

作　　者：李锦州[1] 安郁美[1] 王天赤[1] 俞志刚[1] 

机构地区：[1]哈尔滨师范大学化学系,哈尔滨150080

出　　处：《无机化学学报》2004年第8期983-986,共4页Chinese Journal of Inorganic Chemistry

基　　金：教育部重点科研基金(No.02053);黑龙江省自然科学基金(No.B01鄄06);省高校骨干教师创新计划资助项目。

摘　　要：A new amino-acid Schiff base, 1-phenyl-3-methyl-4-(2-thenoyl) pyrazolone-5-β-alanine (HL) and its ten rare earth complexes have been synthesized. On the basis of elemental analysis and molar conductance, the general formula of the complexes, ·nH2O (RE=La, Nd, Eu, Tb, Y, n=2; RE= Pr, Sm, n=1; RE= Dy, Er, Yb, n=3), is given. They were characterized by IR, UV-visible, 1H NMR, 13C NMR and fluorescence. The results show that the rare earth ions exhibit coordination of eight in the complexes.The antibacterial experiments indicate that they have high antibacterial activities against S. Aureus, B. Subtillis, E. Coli, E. Carotovora and C. Flaccumfaciens.A new amino-acid Schiff base, 1-phenyl-3-methyl-4-(2-thenoyl) pyrazolone-5-beta-alanine (HL) and its ten rare earth complexes have been synthesized. On the basis of elemental analysis and molar conductance, the general formula of the complexes, [REL2NO3](.)nH(2)O (RE=La, Nd, Eu, Tb, Y, n=2; RE=Pr, Sm, n=1; RE=Dy, Er, Yb, n=3), is given. They were characterized by IR, UV-visible, H-1 NMR, C-13 NMR and fluorescence. The results show that the rare earth ions exhibit coordination of eight in the complexes. The antibacterial experiments indicate that they have high antibacterial activities against S. A areus, B. Subtillis, E. Coli, E. Carotovora and C. Flaccumfaciens.

关 键 词：噻吩甲酰基吡唑啉酮缩氨基酸 稀土 配合物 合成 表征 生物活性 席夫碱 

分 类 号：O614.33[理学—无机化学] O641.4[理学—化学]