短期胰岛素强化治疗初发2型糖尿病96例  

Follow-up of Newly-diagnosed Type 2 Diabetes 96 Cases Treated with Short-term Intensive Insulin Therapy

作　　者：徐晓华 胡素银[2] 

机构地区：[1]浙江省金华市金东区第二人民医院,金华321035 [2]浙江省金华市中心医院

出　　处：《浙江中医药大学学报》2011年第2期167-168,共2页Journal of Zhejiang Chinese Medical University

摘　　要：[目的]对新诊断的2型糖尿病(T2DM)患者给予胰岛素强化治疗观察疗效。[方法]观察、随访、回顾性分析金华市中心医院96例新诊断的T2DM经胰岛素强化治疗1～2月后血糖控制情况及胰岛素分泌功能的变化。[结果]短期胰岛素强化治疗2周后79例(82.29%)的患者血糖控制达标,空腹C肽、餐后2hC肽较治疗前比较有明显升高(P<0.01),胰岛素分泌功能部分恢复(P<0.01),4周后91例(94.79%)患者血糖控制达标,胰岛素分泌功能明显恢复,胰岛素用量明显减少(P<0.01)。[结论]胰岛素强化治疗后糖尿病患者血糖迅速达标,消除高血糖的毒性作用,可改善胰岛β细胞功能。[Objective] To investigate the effect of short-term intensive insulin therapy in newly-diagnosed type 2 diabetic patients.[Methods]96 newly-diagnosed type 2 diabetes patients were treated with intensive insulin therapy for 1-2months,blood glucose level and insulin secretion were observed and assessed before and after treatment.[Results] After 2-week intensive insulin therapy,the excellent glycemic control was achieved in 79 out of 96 patients,the level of fasting C-peptide and 2 hour C-peptide were increased significantly,meanwhile insulin secretion function was recovered partly.As the treatment period was extended to 4 weeks,91 patients achieved good glycemic control and insulin secretion function was dramatically recovered,while the obvious decrease of insulin dosage was observed.[Conclusion] Intensive insulin therapy could provide good glycemic control rapidly,rescind high glucose toxicity and improve islet β-cell function.

关 键 词：2型糖尿病 胰岛素 强化治疗 

分 类 号：R2[医药卫生—中医学]