小儿抗早熟颗粒对SD大鼠模型雌二醇的调控作用研究  

Relative Study on the Regulation of Children Anti-premature Granule on Model SD Rats' Estradiol

作　　者：陈祺[1] 戴方伟[2,3] 邵国民[1] 萨晓婴[2] 

机构地区：[1]浙江中医药大学附属第一医院,杭州310006 [2]浙江省医学科学院实验动物中心 [3]浙江大学动物科学学院

出　　处：《浙江中医药大学学报》2011年第2期226-227,233,共3页Journal of Zhejiang Chinese Medical University

基　　金：浙江省中医管理局课题(No:2003C047)~~

摘　　要：[目的]研究小儿抗早熟颗粒对特发性性早熟模型大鼠的干预作用。[方法]建立大鼠性早熟模型,通过设立对照组,观察小儿抗早熟颗粒对性早熟大鼠的第二性征及血清中的E2(雌二醇)等的干预作用。[结果]模型组SD大鼠的阴门开启和建立性周期的时间显著提前;药物组SD大鼠的性周期时间延缓;正常组的子宫脏器系数与模型组、药物组无差异差异;卵巢脏器系数差异显著:模型组最高,药物组最小;E2模型组最高,药物组和正常组低。[结论]小儿抗早熟颗粒能延迟SD大鼠阴道开口平均日龄,降低卵巢脏器系数,控制E2过度升高,延缓性发育。[Objective] To study the cure effect of Children Anti-premature Granule on specific neoteny model rats.[Method] Randomly divide SD rats into normal,model,medicinal groups.Among which,model and medicinal groups had hype injection of danazol;the medicinal group had the said granule;normal one had equal water.Take wet weight of uterus and ovary for organs coefficient.[Result] In model group,the cunnus opening and setting sexual period of SD rats were much advanced;that of medicinal group was delayed;there's no marked difference between model and medicinal groups on uterus coefficient,but marked difference on ovary;and no obvious difference between medicinal and normal group on E2 too.[Conclusion] Danazole hype injection can induce SD rats premature model;the granule can delay cunnus opening,reduce ovary coefficient,control over rise of E2,delay sexual development,and offer experimental base for the granule treating clinical neoteny.

关 键 词：性早熟 小儿抗早熟颗粒 SD大鼠 雌二醇 

分 类 号：R2[医药卫生—中医学]