帕瑞昔布用于妇科腹腔镜手术超前镇痛  

Preemptive Analgesic Effects with Parecoxib in Gynecologic Laparoscopic Surgery

作　　者：肖永[1] 陈桂珊[1] 李元涛[1] 苏娇玲[1] 吴铭广[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院麻醉科,广东深圳518028

出　　处：《郧阳医学院学报》2011年第3期301-303,共3页Journal of Yunyang Medical College

摘　　要：目的:评价帕瑞昔布超前镇痛在妇科腹腔镜手术中的效果和安全性。方法:将80例择期行妇科腹腔镜手术患者随机分为观察组和对照组(n=40)。观察组于麻醉诱导前和手术结束前30 min各静脉注射帕瑞昔布40mg。用视觉模拟评分法(VAS)评估患者术前,苏醒时,术后4、8、12 h疼痛程度,记录苏醒和拔管时间及术后需镇痛药物剂量,并观察不良反应发生情况。结果:2组患者在苏醒和拔管时间上无统计学差异(P>0.05)。观察组苏醒时,术后4、8 h VAS均低于对照组(P<0.05),术后12 h无差异。观察组术后需要镇痛药物需求率及咽部疼痛发生率低于对照组(P<0.05),但恶心、呕吐、躁动的发生率无差异。结论:帕瑞昔布超前镇痛应用于妇科腹腔镜手术,能有效缓解术后疼痛,减少术后镇痛药的使用及不良反应发生,不影响全麻苏醒。Objective To evaluate the effective and safety of preemptive analgesic with parecoxib in patients undergone gynecologic laparoscopic surgery.Methods Eighty patients scheduled for elective gynecologic laparoscopic surgery were randomly divided into parecoxib group and control group.The patients of parecoxib group were given parecoxib 40 mg before induction and 30 min before surgery,respectively.The intensity of pain was evaluated by using visual analogue scale(VAS) at the following time points,before operation,the point of awareness,4 h,8 h and 12 h after operation.The incidence rates of nausea,restlessness,vomiting and pain in throat after surgery and sleep states were recorded.Results There were no significant differences in awakening time and extubation time between two groups.The VAS scores at the points of awareness,4 h,8 h after surgery in parecoxib group were lower than those of control group.There were no significant differences in VAS scores at 12 h between two groups.Compared with control group,the patients of parecoxib group had significantly lower consumption of other analgesics.The incidence rates of nausea and vomiting had no difference in two groups.The incidence rate of pain in throat after surgery in parecoxib group was lower than that of control group(P<0.05).Conclusion Pre-operation parecoxib administration in patients undergone gynecologic laparoscopic surgery could relieve postoperative pain,reduce the other analgesics consumption and side effects,which had no obviously effect on awareness time.

关 键 词：帕瑞昔布 超前镇痛 腹腔镜手术 

分 类 号：R614[医药卫生—麻醉学]