Toll样受体4与器官移植排异  

TLR4 and organ transplant rejection

作　　者：赵毅[1] 蔡真[1] 

机构地区：[1]浙江大学医学院附属第一医院骨髓移植中心,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2011年第5期495-500,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(No.30772502);卫生部科学研究基金-浙江省医药卫生重大科技计划项目基金(WKJ2009-2-022)

摘　　要：器官移植是目前治疗恶性疾病的方法之一,而移植相关并发症制约了器官移植的进一步发展。其中,移植物排斥是移植后高死亡率的主要原因。Toll样受体4(TLR4)在先天免疫和免疫耐受中是个关键分子,但在器官移植后移植物排斥中的作用目前尚不明确。文中将对TLR4信号途径在器官移植后移植物排斥中如何通过调控抗原递呈细胞(APC)成熟、活化T细胞、引发免疫攻击的分子机制作一综述。Organ transplant has become one of the strategies for treatment of malignant disease.The transplant-related complications restricted the further development of organ transplantation;graft rejection is most prominent among these complications,which remains a major cause of morbidity and mortality after organ transplant.Toll like receptors 4(TLR-4) has been shown as a key molecule in innate immunity and immune tolerance.The role of TLR4 in graft rejection after organ transplant is still unknown.This article will review the role and the mechanism of TLR4 to control APC mature,activate T cells,trigger immune attack to organ graft;therefore bring new insights into the pathophysiology of graft rejection and foster the development of new therapies to control graft rejection after organ transplant.

关 键 词：TOLL样受体4 器官移植 移植物排斥 

分 类 号：R392.4[医药卫生—免疫学]