microRNAs在代谢综合征中的研究进展  

Research Progress of microRNAs in Metabolic Syndrome

作　　者：冯新星[1] 孙凯[1] 宋雷[1] 

机构地区：[1]中国医学科学院阜外心血管病医院心内科,北京100037

出　　处：《中国分子心脏病学杂志》2011年第4期241-244,共4页Molecular Cardiology of China

基　　金：国家重点基础研究发展计划 (2010CB732601)

摘　　要：近年来代谢综合征发病率持续攀升,造成了巨大的社会经济负担。传统的治疗方式主要包括生活方式干预和药物治疗,但都未能取得理想的治疗效果。microRNAs在诸如脂肪细胞分化、代谢整合、胰岛素抵抗和食欲调节等大多数生物过程均起到重要的调节作用。本文讨论了microRNAs在代谢综合征相关组份肥胖、糖代谢异常、血脂异常、高血压中的研究进展。microRNAs表达和代谢综合征相关组份的密切联系表明采用这些分子作为预测疾病进程的新的生物标记物以及治疗干预的靶点的可行性。The incidence of metabol ic syndrome continues to rise, leading to tremendous socioeconomic burden. The traditional t reatment , including lifestyle changes and medical therapies, couldn’t meet the expected effect. MicroRNAs play important regulatory roles in variety of biological processes such as adipocyte differentiation, metabolic integration, insulin resistance and appetite regulation. Therefore the research progress of metabol ic syndrome related compo nents as obesity, metabol ism abnormality of glucose and lipid ,hypertension is discussed. The clos e relationship between microRNAs’expression and those components highlights the potential of using microRNAs as therapeutic targets and novel biomarkers to predict the progress of these diseases.

关 键 词：MICRORNAS 代谢综合症 糖代谢 脂代谢 肥胖 高血压 

分 类 号：R589[医药卫生—内分泌]