慢性肾衰竭患者血清Hcy检测的临床价值  

Clinical values of serum hcy test for chronic renal failure (CRF) patients

作　　者：沈罡[1] 季军 

机构地区：[1]济南军区青岛第二疗养院 [2]青岛市401医院

出　　处：《中国疗养医学》2011年第5期461-462,共2页Chinese Journal of Convalescent Medicine

摘　　要：目的研究慢性肾衰竭(CRF)患者血清总同型半胱氨酸(tHcy)浓度的变化。方法采用循环酶法测定98例CRF患者和100例健康人血清tHcy的含量,并进行统计分析。结果血清tHcy浓度CRF患者显著高于正常对照组(P<0.01),且Ⅴ期患者显著高于Ⅳ期患者(P<0.01),Ⅳ期患者显著高于Ⅲ期患者(P<0.01)。结论 CRF患者血清tHcy浓度明显升高,且随着病情的加重,血清tHcy浓度呈逐渐上升趋势,检测血清tHcy浓度对了解CRF患者病情具有重要意义。Objective To study the concentration of plasma total homocysteine(tHcy)in patients with chronic renal failure (CRF). Methods 98 chronic renal failure patients and 100 health individuals were chosen to measure the level of tHcy using Enzymatic cycling assay method,results then were analysed with t-test.Results The mean level of tHcy in CRF patients was significantly higher than that in normal controls(P<0.01),and the level of plasma tHcy was significantly higher in stage Ⅴ than in stage Ⅳ in CRF patients,and the level of plasma tHcy was significantly higher in stage Ⅳ than in stage Ⅲ in CRF patients.Conclusion The level of plasma tHcy were significantly elevated in patients with CRF,and there is a trend that the level of plasma tHcy increased with severity of CRF,and measuring the level of plasma tHcy has great value to know the degree of CRF.

关 键 词：同型半胱氨酸 慢性肾衰竭 临床价值 

分 类 号：R692.5[医药卫生—泌尿科学]