1-羟乙基-5-巯基-1H-四唑的合成  

Synthesis of 1-Hydroxyethyl-1H-tetrazole-5-thiol

作　　者：肖斌[1] 沈毅[1] 周辉[1] 李勤耕[1] 

机构地区：[1]重庆医科大学药学院,重庆400016

出　　处：《中国医药工业杂志》2011年第5期330-331,350,共3页Chinese Journal of Pharmaceuticals

摘　　要：以乙醇胺、二硫化碳和氯苄为起始原料,经缩合、取代、加成、成环及脱保护反应制得氟氧头孢关键中间体1-羟乙基-5-巯基-1H-四唑,总收率约67%。The improved synthesis of 1-hydroxyethyl-1H-tetrazole-5-thiol,the key intermediate of flomoxef,had been achieved with an overall yield of 67% by the condensation of 2-aminoethanol with CS2 and benzyl chloride,followed by replacement,addition,cyclization and deprotection.

关 键 词：1-羟乙基-5-巯基-1H-四唑 氟氧头孢 中间体 合成 

分 类 号：R9[医药卫生—药学]