电针百会、风府穴对学习记忆障碍大鼠的认知行为及脑内BDNF的影响  

Effects of Electroacupuncture at Point Baihui and Fengfu on the Expressions of BDNF and the Cognitive Function in Dementia Rats

作　　者：张迪[1] 孙阳[2] 王丽芹[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《中医药学报》2011年第3期113-115,共3页Acta Chinese Medicine and Pharmacology

基　　金：黑龙江省科技厅青年基金计划项目(编号:QC08C75)

摘　　要：目的:研究电针刺激百会和风府穴对学习记忆障碍的痴呆大鼠脑内脑源性神经营养因子的影响。方法:选取纯系雄性Wistar大鼠48只,随机分4组,即为假手术组、模型组、针刺组和西药组。应用D-半乳糖快速衰老及IBO脑内双侧Meynert核立体定位注射法制备学习记忆障碍痴呆大鼠模型。给予百会及风府穴电针刺激。结果:对大鼠百会及风府穴施以电针可以减少模型大鼠在行为学检测中遭受电击的次数,降低受到电击时间,增强BDNF在脑组织内的表达。结论:针刺能够上调模型鼠脑内BDNF的表达,促进BDNF发挥其对神经细胞的营养作用,改善大鼠的学习记忆能力。Objective:To observe the effects of electroacupuncture at point baihui and fengfu on the expressions of brain-derived neurotrophic factor(BDNF) and the cognitive function in dementia rats.Methods:Fourty-eight male Wister rats were randomly divided into four groups,control group(n=12),model group(n=12),acupuncture group(n=12) and medicine group(n=12).Model rats of dementia were established in Wistar rats by intraperitoneral injection of D-galactose for six weeks combined with ibotenic acid injection into bilateral nucleus basalis of Meynert.Treated with electroacupuncture at point baihui and fengfu.Results:Electroacupuncture at point baihui and fengfu can reduce the times and the time of tip-and-run on Rats in shuttle box.It can improve the expression of BDNF.Conclusion:Electroacupuncture at point baihui and fengfu can improve the cognitive function and increase the contents of BDNF in dementia rats.

关 键 词：电针治疗 学习记忆 脑源性神经营养因子 痴呆 

分 类 号：R2[医药卫生—中医学]