瑞舒伐他汀钙对冠心病合并糖尿病患者辅助性T细胞亚群的干预作用  

Effect of rosuvastatin on the change of Th1/Th2 subsets in coronary heart disease with diabetes

作　　者：李晓燕[1] 张华丽[1] 韩淑芳[1] 张红明[1] 康玲[1] 耿雪[1] 

机构地区：[1]济南军区总医院心内科,250031

出　　处：《中华临床医师杂志（电子版）》2011年第13期3712-3715,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的通过观察瑞舒伐他汀钙对冠心病合并糖尿病患者的外周血中辅助性T细胞亚群的干预作用,推测瑞舒伐他汀钙在治疗过程中的非调脂作用。方法选取冠心病合并糖尿病患者90例,随机分为安慰剂对照组(45例)和瑞舒伐他汀钙治疗组(45例),在治疗前及给予安慰剂或瑞舒伐他汀钙(10mg/晚)治疗1个月后,提取外周血单个核细胞(PBMC),流式细胞术检测Th1/Th2细胞水平。结果 (1)瑞舒伐他汀钙组治疗1个月后,血浆中总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)与治疗前及对照组相比,均有显著性下降,差异具有统计学意义(P<0.05),高密度脂蛋白胆固醇(HDL-C)和甘油三酯(TG)变化无统计学意义;(2)瑞舒伐他汀钙组治疗1个月后,患者外周血中Th1细胞水平与治疗前及对照组相比显著降低,差异具有统计学意义(P<0.01),Th2细胞水平与治疗前及对照组相比显著升高,差异具有统计学意义(P<0.05)。结论瑞舒伐他汀钙除具有较强的调脂作用外,还可以改善外周血辅助性T细胞亚群的失衡,从而延缓冠心病合并糖尿病患者的动脉粥样硬化进程,此可能为他汀类药物抗动脉粥样硬化的机制之一。Objective To investigate the effect of rosuvastatin on the change of Th1/Th2 subsets in coronary heart disease with diabetes.Methods Selected 90 patients with both coronary heart disease and diabetes mellitus.These cases were randomly divided into placebo control group(45 cases) and rosuvastatin calcium treatment group(45 cases).Before treatment,the peripheral blood mononuclear cells(PBMC) were extracted to test the Th1/Th2 cell ratio by flow cytometry.After taking placebo or rosuvastatin calcium(10 mg/d) for a month,PBMC were extracted to test the Th1/Th2 cell ratio by flow cytometry again.Results(1)Plasma total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)of resuvastatin calcium group compared with those of placebo control group and those before treatment were significantly decreased(P<0.05),high density lipoprotein cholesterol(HDL-C) and triglyceride(TG) were no significant change.(2)Compared with placebo control group and before treatment,the Th1 cell ratio was significantly lower(P<0.01).The Th2 cell ratio was increased,and there was significant difference(P<0.05).Conclusions Rosuvastatin could intervene with experimental atherosclerotic development in coronary heart disease with diabetes,which mechanism might be that rosuvastatin could suppress the activation of Th1 related cytokines and improve the imbalance of Th1/Th2.

关 键 词：冠心病 糖尿病 T淋巴细胞 辅助诱导 流式细胞术 瑞舒伐他汀钙 

分 类 号：R541.4[医药卫生—心血管疾病] R587.2[医药卫生—内科学]