慢性丙型肝炎合并脂肪肝患者血清网膜素水平与其病毒及代谢因素的相关分析  

Viral and metabolic factors associated with serum level of Omentin in patients with chronic hepatitis C complicated with fatty liver

作　　者：凌伟[1] 温少芳[1] 高萍[1] 张海栋[1] 赵崇山[1] 王琦[1] 刘顺爱[1] 张锦前[1] 成军[1] 

机构地区：[1]首都医科大学附属北京地坛医院传染病研究所,100015

出　　处：《中华临床医师杂志（电子版）》2011年第16期4632-4635,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨慢性丙型肝炎(CHC)并发脂肪肝患者血清网膜素水平及其与代谢因素的相关性。方法选择初次就诊未进行抗病毒治疗的93例CHC患者,根据患者是否伴有脂肪性肝病(FLD)将患者分为两组:FLD组(45例)和非FLD组(48例)。比较两组患者的一般状况,如性别、年龄、体重指数(BMI)、腰臀比(WHR)等;HCV基因型、病毒载量等病毒学相关指标;肝脏酶学指标(ALT、AST);血糖[空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)];血脂(TG、TC)以及网膜素水平等。结果 FLD组与非FLD组患者的BMI存在统计学差异。FLD组患者的TG水平明显高于非FLD组(P<0.05),而FLD组患者的ALT、AST、FINS、HOMA-IR以及血清网膜素水平明显低于非FLD组(P<0.05)。两组间病原学因素差异无统计学意义。血清网膜素水平与WHR、BMI、FINS、HOMA-IR、TG呈显著负相关。多元逐步回归分析发现,HOMA-IR是血清网膜素水平的独立相关因素(R2=0.889,P<0.01)。结论 CHC患者伴发FLD与血清网膜素水平下降密切相关,而血清网膜素水平与病毒本身无明确相关性。Objective To investigate the viral and host factors associated with serum level of Omentin in patients with chronic hepatitis C complicated with fatty liver.Methods Total of 93 patients with untreated chronic hepatitis C were enrolled in Beijing Ditan Hospital from 2007 to 2010.The patients were divided into two groups depending on the diagnosis of fatty liver:group with fatty liver disease(FLD)(45 patients) and group without FLD(48 patients).The two groups were compared in terms of gender,age,BMI,WHR,ALT,AST,GGT,FPG,FINS,HOMA-IR,TG,TC,Omentin,HCV genotype and load of HCV RNA.Results Significant difference was found in BMI between the two groups(P<0.05).In the group of chronic hepatitis C with FLD,TG was significantly higher than that in the group without FLD(P<0.05).However,in the group of chronic hepatitis C with FLD,the ALT,AST,FINS,HOMA-IR and serum level of Omentin were significantly lower than those in the group without FLD(P<0.05).Partial correlation analysis showed that the serum level of Omentin was negatively correlated to WHR、BMI、FINS、HOMA-IR and TG.Multiple linear regression showed that HOMA-IR was independent variable of serum level of Omentin.Conclusions The serum level of Omentin was lower in CHC patients with FLD than those without FLD,it may be not directly associated with HCV.

关 键 词：肝炎 丙型 慢性 脂肪肝 网膜素 

分 类 号：R512.63[医药卫生—内科学]