FTO基因多态性与儿童肥胖的关联研究  

Effects of FTO gene on weight change of children in a follow-up study

作　　者：陈燕燕 沈月[2] 李光伟 王兴宇[2] 王金平[3] 姜亚云[3] 黎辉[3] 

机构地区：[1]中国医学科学院北京协和医学院阜外心血管病医院内分泌与心血管病诊治中心,北京100037 [2]北京高血压联盟研究所 [3]大庆市第一医院心血管病研究室

出　　处：《中华临床医师杂志（电子版）》2011年第20期6007-6011,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨FTO基因rs9939609多态性对儿童体重增加的影响。方法选取大庆地区390例儿童进行5年随访,入选时和第5年分别测定身高、体重,并检测FTO基因rs9939609多态性,以多因素分析探讨各基因型与儿童体重及体重指数(BMI)增加的关系。结果 (1)调整性别因素影响后,初访时各基因型组体重及BMI均无统计学差异。(2)5年后随访,AA基因型儿童体重明显高于TT基因型儿童[(41.32±7.30)kgvs.(36.30±8.77)kg,P<0.05],BMI亦如此[(19.72±0.92)kg/m2vs.(17.74±0.20)kg/m2,P<0.05]。从体重变化来看,AA基因型儿童5年后体重及BMI增加均明显高于TT基因型(P<0.05)。(3)调整性别及看电视时间影响因素后,AA基因型与BMI的变化仍独立相关。结论 FTO基因促进儿童时期(5岁以后)体重的增加,且不因看电视时间等环境因素影响而减弱。Objective To investigate the association of FTO gene rs9939609 polymorphism with weight gain in children.Methods 390 children in elementary schools in Daqing city were enrolled in the present study.Body heights,weights were measured at 1st,5th year.The rs99396099 single nucleotide polymorphism (SNP) in FTO was genotyped by allele-specific real-time PCR assay.Relationship between FTO gene and children′s weight,the common effects of genetic and environmental factors were analyzed by multivariate regression analysis with SAS software package.Results (1) Adjusted sex,there was not significant differences among three genotypes with weight and BMI at 5 years old.(2) After follow-up 5 years,the body weight in group with genotype of AA was significant higher than that in TT group [(41.32±7.30)kg vs.(36.30±8.77)kg,P<0.05],and also BMI [(19.72±0.92)kg/m2 vs.(17.74±0.20)kg/m2,P<0.05].As the change in weight and BMI from 5 to 10 years old,the genotype of AA was significant higher than that in TT group (P<0.05).(3) Multivariate regression analysis showed that the change in BMI positively correlated with AA genotype after adjustment for sex and TV viewing time at the baseline.Conclusions FTO gene rs9939609 polymorphism significantly correlate with body weight in children,which enhance weight gain after 5 years of age.The increased body weights and BMI in subjects with AA genotype are not decreased by the TV viewing time.

关 键 词：多态性 单核苷酸 儿童 体重 FTO基因 

分 类 号：R723.14[医药卫生—儿科]