普伐他汀联合髓芯减压术治疗激素性兔股骨头坏死的实验研究  

Experimental study of pravastatin combined with core decompression on treatment of corticosteroid-induced femoral head osteonecrosis in rabbits

作　　者：乐锦波[1,2] 杜远立[1,2] 向选平[1,2] 茹能[1,2] 邓娟娟 武斌[1,2] 

机构地区：[1]三峡大学人民医院 [2]宜昌市第一人民医院骨科,湖北宜昌443000

出　　处：《中华临床医师杂志（电子版）》2011年第21期6226-6230,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的研究普伐他汀联合髓芯减压术治疗激素性兔股骨头坏死对组织病理学、骨形态发生蛋白2(BMP2)和血管内皮生长因子(VEGF)mRNA表达水平的影响。方法 45只实验大白兔制作成激素性股骨头坏死模型后随机分为三组:髓芯减压术治疗组(A组),普伐他汀联合髓芯减压术治疗组(B组)和模型组(C组),每组各15只。观察各组各时期兔股骨头毛细血管数、管径、骨陷窝空缺百分比以及BMP2、VEGFmRNA表达水平。结果 A、B两组第4周BMP-2、VEGFmRNA表达水平(7.4±1.1,8.0±1.0;0.118±0.027,0.129±0.023)与C组比较无统计学差异(7.2±0.8;0.117±0.024)(P>0.05)。而B组第8周和第12周BMP-2、VEGFmRNA表达水平(10.5±2.4,13.8±3.2;0.341±0.047,0.562±0.059)明显高于A组(8.0±1.7,8.8±2.0;0.137±0.033,0.149±0.048)、C组(7.6±1.6,7.7±1.8;0.126±0.035,0.131±0.041)(P<0.05);且随治疗时间延长,B组BMP-2、VEGFmRNA表达水平明显升高(P<0.05)。结论普伐他汀联合髓芯减压术可明显上调股骨头BMP-2、VEGFmRNA的表达水平,是治疗激素性股骨头坏死的有效方法。Objective To observe the expression levels of BMP2,VEGF mRNA and histopathology of pravastatin combined with core decompression on treatment of corticosteroid-induced femoral head osteonecrosis in rabbits.Methods 45 experimental rabbits were made to the model of steroid-induced osteonecrosis and were randomly divided into 3 groups:core decompression treatment group (group A),pravastatin combined with core decompression treatment group (group B) and the model group (group C),every group was 15 rabbits.The capillary number,diameter,percentage of vacant lacunae,BMP2 and VEGF mRNA in the femoral head at different periods were observed.Results The expression of BMP-2 and VEGF mRNA in groups A,B (7.4±1.1,8.0±1.0;0.118±0.027,0.129±0.023) at 4 weeks showed no significant difference with groups C (7.2±0.8;0.117±0.024) (P>0.05),while the expression of BMP-2 and VEGF mRNA in group B (10.5±2.4,13.8±3.2;0.341±0.047,0.562±0.059)at 8 weeks and 12 weeks were significantly higher than that of group A(8.0±1.7,8.8±2.0;0.137±0.033,0.149±0.048),group C (7.6±1.6,7.7±1.8;0.126±0.035,0.131±0.041) (P<0.05),and with prolonged treatment,the expression of BMP-2 and VEGF mRNA in group B were significantly higher (P<0.05).Conclusions The treatment of pravastatin combined with core decompression can significantly increased the expression levels of BMP-2,VEGF mRNA in femoral head.It is an effective method to treat the femoral head necrosis.

关 键 词：减压术 外科 股骨头坏死 骨形态发生蛋白受体 Ⅱ型 血管内皮生长因子类 普伐他汀 

分 类 号：R687.4[医药卫生—骨科学]