脑胶质瘤术后VMAT与IMRT放疗技术间比较  

A Comparison of Volumetric Modulated Arc Therapy and Intensity-Modulated Radiotherapy for Postoperative Glioma

作　　者：张矛[1] 金海国[1] 卜明伟 孙宝胜[1] 孙术全 苏清秀[1] 李玉平[1] 

机构地区：[1]吉林省肿瘤医院放疗三科,吉林长春130012

出　　处：《中国医学物理学杂志》2011年第6期2959-2963,共5页Chinese Journal of Medical Physics

基　　金：吉林省自然科学基金(No.201015235)

摘　　要：目的:比较脑胶质瘤术后容积旋转调强(Volumetric Modulated Arc Therapy,VMAT)计划与静态调强(IntensityModulated Radiation Therapy,IMRT)计划,讨论VMAT的剂量学特性,分析VMAT在脑胶质瘤术后放射治疗中的应用。材料与方法:选取10例颅内肿瘤患者,采用Monaco治疗计划系统,分别制作VMAT计划与IMRT计划,处方剂量全部为PTV:60 Gy/30f。比较两组计划的剂量分布图、DVH图、适形度指数(CI)、均匀指数(HI)、治疗时间、治疗跳数(MU)、危及器官受量。结果:两组计划靶区剂量分布及适形度均较好,CI、HI数相近(P>0.05),但VMAT组的治疗时间和MU均优于IMRT组(P<0.05)。在危及器官受量方面,两组计划的脑干与视交叉的平均剂量相近(P>0.05),而视神经、视网膜、晶体和周围正常脑组织的平均剂量,VMAT组明显低于IMRT组(P<0.05)。结论:在脑胶质瘤术后的放射治疗中,VMAT与IMRT的靶区剂量分布相近。VMAT的优势在于大大缩小缩短治疗时间、减少MU,同时减少了部分危及器官受量。Objective: This planning study compares IMRT with VMAT for discussing the dosimetric characteristics of VMAT in the intracranial tumor radiation therapy.Materials and Methods: Totally 10 treated patients of intracranial tumors were replanned to 60 Gy in 30 fractions with VMAT and IMRT using Monaco treatment planning system.We compared DVH,conformal index,homogeneity index,treatment time,monitor units,and the dose of organs at risk between the two groups.Results: There was equivalent CI and HI(P >0.05),VMAT significantly reduced treatment time and monitor units(P <0.05).To the the dose of organs at risk,the mean of brainstem and optic chiasm were similar(P >0.05),while the men of optic nerve,retina,lens,and the normal brain,VMAT significantly lower than the IMRT group(P <0.05).Conclusions: Compared with IMRT,VMAT achieves better OAR sparing while using fewer monitor units and less time to treat intracranial tumor.

关 键 词：VMAT IMRT 脑胶质瘤 

分 类 号：R312[医药卫生—基础医学]